(<i>R</i>)-panaxadiol by whole cells of filamentous fungus <i>Absidia coerulea</i> AS 3.3382

<p>The microbial transformation of 20(<i>R</i>)-panaxadiol (<b>PD</b>) by the fungus <i>Absidia coerulea</i> AS 3.3382 afforded three new and three known metabolites. The structures of the metabolites were characterized as 3-oxo-20(<i>R</i>)-panaxadiol (<b>1</b>), 3-oxo-7β- hydroxyl-20(<i>R</i>)-panaxadiol (<b>2</b>), 3-oxo-22β-hydroxyl-20(<i>R</i>)-panaxadiol (<b>3</b>), 3-oxo- 7β,22β-dihydroxyl-20(<i>R</i>)-panaxadiol (<b>4</b>), 3-oxo-7β,24β-dihydroxyl-20(<i>R</i>)-panaxadiol (<b>5</b>), and 3-oxo-7β,24α-dihydroxyl-20(<i>R</i>)-panaxadiol (<b>6</b>). Among them, <b>2-4</b> were new compounds. In addition, compounds <b>3</b> and <b>4</b> exhibited significant anti-hepatic fibrosis activity.</p>