<i>N</i>-Hydroxypyridones, Phenylhydrazones, and a Quinazolinone from <i>Isaria farinosa</i>
2011-01-28T00:00:00Z (GMT) by
New <i>N</i>-hydroxypyridones, militarinones E (<b>1</b>) and F (<b>2</b>), phenylhydrazones, farylhydrazones A (<b>3</b>) and B (<b>4</b>), a quinazolinone, 2-(4-hydroxybenzyl)quinazolin-4(3<i>H</i>)-one (<b>5</b>), and the known militarinones A (<b>6</b>) and B (<b>7</b>) were isolated from cultures of the <i>Cordyceps</i>-colonizing fungus <i>Isaria farinosa</i>. The structures of <b>1</b>−<b>5</b> were elucidated by spectroscopic methods, and <b>3</b> was confirmed by X-ray crystallography. The absolute configuration of the C-4′ secondary alcohol in <b>1</b> was deduced via the circular dichroism data of the <i>in situ</i> formed [Rh<sub>2</sub>(OCOCF<sub>3</sub>)<sub>4</sub>] complex. Compounds <b>1</b> and <b>6</b> showed significant cytotoxicity against A549 cells, whereas <b>7</b> was active against <i>Staphylococcus aureus</i>, <i>Streptococcus pneumoniae</i>, and <i>Candida albicans</i>.