ol400672c_si_002.cif (18.19 kB)
N‑Heterocyclic Carbene Catalyzed Oxidative Coupling of Aldehydes with Carbodiimides under Aerobic Conditions: Efficient Synthesis of N‑Acylureas
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posted on 2013-05-03, 00:00 authored by Takahiro Soeta, Yuhta Tabatake, Shuhei Fujinami, Yutaka UkajiThe oxidative coupling reaction of aldehydes with N,N′-disubstituted carbodiimides catalyzed by N-heterocyclic carbenes under aerobic conditions has been achieved. This reaction gives the corresponding N-acylurea derivatives in good to high yields. Various kinds of aldehydes including aliphatic ones and carbodiimides are applicable to this reaction.