<i>elt-2</i> and the p38 pathway co-regulate immune protection.

<p><i>A</i>. Overlaps between <i>sek-1</i> (or <i>pmk-1)</i> targets (Troemel <i>et al</i>., 2006), and <i>elt-2</i> targets; gene numbers are shown. <i>B</i>, Survival curves for wildtype and <i>sek-1</i> animals fed with designated RNAi’s during early adulthood, followed by <i>P</i>. <i>aeruginosa</i> infection; averages ± SDs for three plates (N = 92–151 per group,*p<0.0001 (Logrank test)); shown is a representative of several experiments with similar results. <i>C</i>, <i>P</i><sub><i>F55G11</i>.<i>2</i></sub>::<i>gfp</i> worms fed with RNAi as designated during adulthood and exposed to <i>P</i>. <i>aeruginosa</i> (PA, 4 hours, N = 10–19 per group) or <i>E</i>. <i>coli</i> (EC, N = 19–25); signal quantification shown on the right, *p<3xE-6, ttest. Shown is a representative experiment of two with similar results. <i>D-F</i>, Gene expression in wildtype or <i>pmk-1(km25)</i> loss-of-function animals fed with designated RNAi’s during larval development. Shown are averages and SDs for two independent experiments <i>D</i>,<i>F</i>, basal expression (values and statistics relative to values in wt;EV (set to 1 and therefore not shown). <i>E</i>, Induction following 12 hours of <i>P</i>. <i>aeruginosa</i> infection, relative to basal expression in similarly-treated worms grown on <i>E</i>. <i>coli</i>. *p<0.01, **p<0.0005 (paired t-test); asterisks mark significant differences for individual gene(s), or for each of the genes in a group designated by a line.</p>