<i>dhfr</i> triple mutant H<sub>e</sub> changes over time (50R/51I/108N).

<p>The figure shows variation in H<sub>e</sub> surrounding <i>dhfr</i> for parasites carrying a 50R/51I/108N mutants during the 1980s (n = 14) and 1990s (n = 92). Note that H<sub>e</sub> around the triple mutants seems similar between the two decades. The two flat, dashed lines represent two different estimates of neutral H<sub>e</sub> in Brazil.</p>