Figure_3.tif (4.51 MB)
cnot8m1061 mutant embryos are not generally delayed in development.
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posted on 2014-12-05, 03:24 authored by Peter Koch, Heiko B. Löhr, Wolfgang DrieverGene expression analysis of emx1, fgf8 and krox20/egr2b in cnot8m1061 mutants and wild-type siblings at 1, 2 and 3 dpf. (A–F) emx1, (G–L) fgf8 and (M–R) krox20/egr2b. Embryos were genotyped by PCR. All pictures show lateral views. Scale bars 100 µm.
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dopaminergic neuron developmentCnot 8 activity differentiallymRNA decay pathwaycaudalcnot 8m mutantsfgf 3 genem 1061 mutationCnot 8 deadenylase componentcontrol genesCnot 8 activity resultsdopaminergic differentiationdisplays deadenylase activitymRNA levelshybridization signal levelsbulk mRNA turnoverm 1061 causesFgf 3Affects Expression LevelsFGF target genes
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