c<i>Hes6-1</i> expression relative to expression of various genes involved in neurogenesis.

2013-02-20T22:02:51Z (GMT) by Filipe Vilas-Boas Domingos Henrique
<p>(A-Oi) Double <i>in situ</i> hybridization shows partial overlapping patterns and co-expression between c<i>Hes6-1</i> (green) and the following genes in spinal cord of E4 embryos: (A-Ci) c<i>Neurog1</i>, (D-Fi) c<i>Neurog2</i>, (G-Ii) c<i>NeuroM</i>, (J-Li) c<i>Hes6-2</i> and (M-Oi) c<i>Delta1</i> (red). (Ci), (Fi), (Ii), (Li), (Oi) are magnifications of the selected areas in (C), (F), (I), (L), (O), respectively. Arrows indicate cells where genes are co-expressed. Horizontal lines in (F) and (Fi) separate the dorsal and ventral domains of the spinal cord. (P) Neuronal differentiation is a step-wise process: differentiating neural progenitors exit the IVZ (inner ventricular zone) and sequentially activate neuronal differentiating genes during migration to the ML (mantle layer). c<i>Hes6-1</i> is transiently expressed in the OVZ (outer ventricular zone), where it is co-expressed with various genes involved in neurogenesis.</p>