figshare
Browse
Figure_4.tif (4.2 MB)

cHes6-1 expression relative to expression of various genes involved in neurogenesis.

Download (0 kB)
figure
posted on 2013-02-20, 22:02 authored by Filipe Vilas-Boas, Domingos Henrique

(A-Oi) Double in situ hybridization shows partial overlapping patterns and co-expression between cHes6-1 (green) and the following genes in spinal cord of E4 embryos: (A-Ci) cNeurog1, (D-Fi) cNeurog2, (G-Ii) cNeuroM, (J-Li) cHes6-2 and (M-Oi) cDelta1 (red). (Ci), (Fi), (Ii), (Li), (Oi) are magnifications of the selected areas in (C), (F), (I), (L), (O), respectively. Arrows indicate cells where genes are co-expressed. Horizontal lines in (F) and (Fi) separate the dorsal and ventral domains of the spinal cord. (P) Neuronal differentiation is a step-wise process: differentiating neural progenitors exit the IVZ (inner ventricular zone) and sequentially activate neuronal differentiating genes during migration to the ML (mantle layer). cHes6-1 is transiently expressed in the OVZ (outer ventricular zone), where it is co-expressed with various genes involved in neurogenesis.

History

Usage metrics

    PLOS ONE

    Keywords

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC