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WT and HIV-1 tg brains were sectioned and stained for Ki-67 reactivity as a measure of cell proliferation.

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posted on 01.10.2014, 02:51 by Christina L. Nemeth, Erica R. Glasper, Constance S. Harrell, Sanjana A. Malviya, Jeffrey S. Otis, Gretchen N. Neigh

(A) HIV-1 tg brains had significantly decreased levels of cell proliferation in the dentate gyrus of the hippocampus as compared to WT brains (*p<0.05). Data are presented as mean ± SEM. (B) Photomicrograph of hemisection containing Ki-67 stained cells in the dentate gyrus of a WT rat. Inset highlights dense region of Ki-67 positive cells, marked with arrows. (C) Photomicrograph of Ki-67 stained cells in a HIV-1 tg rat. Again, insert highlights region of Ki-67 stained cells marked with arrows. Images captured at 20x, scale bar equals 50 µM.