Verrucarin A can selectively kill cancer, but not normal cells.

<p>(A) Verrucarin A can kill a variety of cancer cells. MCF-7, A549, H1299, and PC-3 cells were treated with verrucarin A at different concentrations (0, 0.2, 0.5, 1, 2, 5, 10, and 20 nM) for 72 h, followed by MTS assay. (B) HepG2 cells are sensitive to verrucarin A, but primary hepatocytes are not. HepG2 cells were treated with verrucarin A at different concentrations (0, 0.2, 0.5, 1, 2, 5, 10, and 20 nM) for 48 h. Primary hepatocytes were treated with verrucarin A at different concentrations (0, 2, 5, 10, 20, 50, 100, and 200 nM) for 48 h, followed by MTS assay. (C) Verrucarin A inhibits cancer cell viabilities with potencies in line with its ability to down regulate SRC-3 protein levels.</p>