Table_3.xls (5.5 kB)
Univariate and multivariate Cox analyses of OS in 370 patients with PC not undergoing surgery according to pre-treatment concentrations of plasma YKL-40, IL-6, serum CA 19.9, age, sex and stage.
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posted on 2013-06-26, 08:49 authored by Nicolai A. Schultz, Ib J. Christensen, Jens Werner, Nathalia Giese, Benny V. Jensen, Ole Larsen, Jon K. Bjerregaard, Per Pfeiffer, Dan Calatayud, Svend E. Nielsen, Mette K. Yilmaz, Niels H. Holländer, Morten Wøjdemann, Stig E. Bojesen, Kaspar R. Nielsen, Julia S. JohansenHR = Hazard ratio. CI = Confidence interval. Stage is scored as IIB+III vs. IV. Hi, high concentration; Lo, low concentration.
Multivariate 1: Dichotomized biomarkers. §Plasma YKL-40 was dichotomized (high vs. normal according to the age-corrected upper 95% percentage limit of YKL-40 in healthy subjects). §§Plasma IL-6 was dichotomized (high vs. normal according to 95% percentage limit of IL-6 in healthy subjects, i.e. cut-off 4.5 ng/l). §§§Serum CA 19.9 was dichotomized (high vs. normal according to the cut-off 37 kU/l).
Multivariate 2: The biomarkers are log transformed (log base 2) i.e. hazards are for a twofold difference.
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Diagnostic medicineClinical laboratory sciencesClinical chemistryGastroenterology and hepatologyGastrointestinal cancerspancreasoncologyCancer detection and diagnosisEarly detectionCancers and neoplasmsGastrointestinal tumorsPancreatic cancersurgeryGastrointestinal surgerySurgical oncologymultivariatecoxos370patientspcundergoingpre-treatmentconcentrationsplasmaserumca
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