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Univariate and multivariate Cox analyses of OS in 103 patients operated for PC according to pre-treatment concentrations of plasma YKL-40, IL-6, serum CA 19-9, age, sex, and stage.

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posted on 2013-06-26, 08:49 authored by Nicolai A. Schultz, Ib J. Christensen, Jens Werner, Nathalia Giese, Benny V. Jensen, Ole Larsen, Jon K. Bjerregaard, Per Pfeiffer, Dan Calatayud, Svend E. Nielsen, Mette K. Yilmaz, Niels H. Holländer, Morten Wøjdemann, Stig E. Bojesen, Kaspar R. Nielsen, Julia S. Johansen

HR = Hazard ratio. CI = Confidence interval. Stage is scored as IA+IB+IIA vs. IIB+III. Hi, high concentration; Lo, low concentration.

Multivariate 1: Dichotomized biomarkers. §Plasma YKL-40 was dichotomized (high vs. normal according to the age-corrected upper 95% percentage limit of YKL-40 in healthy subjects). §§Plasma IL-6 was dichotomized (high vs. normal according to 95% percentage limit of IL-6 in healthy subjects, i.e. cut-off 4.5 ng/l). §§§Serum CA 19.9 was dichotomized (high vs. normal according to the cut-off 37 KU/l).

Multivariate 2: The biomarkers are log transformed (log base 2) i.e. hazards are for a twofold difference.

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