Figure_2.tif (331.4 kB)
Two distinct patterns of amino acid substitutions that produce different spatial arrangements of viruses.
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posted on 2011-10-10, 01:49 authored by Kimihito Ito, Manabu Igarashi, Yutaka Miyazaki, Teiji Murakami, Syaka Iida, Hiroshi Kida, Ayato Takada(A) The straight arrangement of viruses. If a series of amino acid substitutions all occur in different positions, then the distance from an ancestor to a mutant should be proportional to the number of substitutions (B). These independent substitutions make a straight arrangement of viruses on the map. (C) The curved arrangement of viruses. If amino acids at particular positions were substituted more than once, the distance from an ancestor to a mutant should be less than the number of substitutions (D). These concentrated substitutions at the same amino acid positions make a curved arrangement of viruses. In both panels, viruses are represented by circles, with illustrative examples of their amino acid sequences and substitutions on them.