Two computational approaches for determining the 3D structure of genomic domains and genomes.

2013-02-20T16:45:08Z (GMT) by Marc A. Marti-Renom Leonid A. Mirny

(A) The first approach uses polymer models to simulate relevant interactions (both physical and biological) that explain experimental observations. (B) The second approach integrates diverse experimental observations to model a conformational ensemble that satisfies the experimental observations.