Two-Way Sensitivity Analysis on Effectiveness and Cost of Directly Observed Therapy.

<p>Each diagonal curve represents a different estimate of effectiveness (log<sub>10</sub> reduction in viral load) of directly observed therapy: −0.5 log<sub>10</sub> (thick line, squared); −0.8 log<sub>10</sub> (thin solid line, diamonds); or −1.5 log<sub>10</sub> (dashed line, triangles). Incremental cost-effectiveness of directly observed therapy relative to self-administered antiretrovirals appears on the Y-axis. At each level of effectiveness, increasing the cost of directly observed therapy increases the cost-effectiveness ratio associated with this intervention; however, only under the most unfavorable cost and effectiveness assumptions does this ratio exceed $50,000 per quality-adjusted life-year (QALY) gained, a commonly cited cost-effectiveness threshold (horizontal dashed line). Values falling below the X-axis indicate that directly observed therapy is cost-saving.</p>

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