Transcriptional importance of STATs, IRF-1, and IRF-7 as supported by cross-signature and cross-module comparisons.

<p>(<b>A</b>) qRT-PCR validation of <i>IFNB1</i> induction. Data were from samples as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038367#pone-0038367-g004" target="_blank">Figure 4</a>. ** for P-value<0.01. (<b>B</b>) Gene overlap of the THP1r2<i>Mtb</i>-induced signature and an active pulmonary TB (PTB) signature <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038367#pone.0038367-Berry1" target="_blank">[13]</a>. (<b>C</b>) Regulatory/TFBS enrichment analysis in promoter regions of the active PTB signature in the form of PWM. (<b>D</b>) Gene overlap analysis of predefined modules and the THP1r2<i>Mtb</i>-induced signature. Only those modules with more than 10% of genes (represented by the proportion of black area in the pie) presented in the THP1r2<i>Mtb</i>-induced signature were displayed. Functional interpretations of modules through literature profiling <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038367#pone.0038367-Chaussabel1" target="_blank">[15]</a> were indicated at lower panel. (<b>E</b>) Regulatory/TFBS enrichment analysis of module M3.1.</p>