Table_2.xls (17.5 kB)

Top genome-wide significant SNPs associated with bone mineral density of the total-body less head, lower limb, upper limb and skull.

dataset

posted on 2014-06-19, 03:23 authored by John P. Kemp, Carolina Medina-Gomez, Karol Estrada, Beate St Pourcain, Denise H. M. Heppe, Nicole M. Warrington, Ling Oei, Susan M. Ring, Claudia J. Kruithof, Nicholas J. Timpson, Lisa E. Wolber, Sjur Reppe, Kaare Gautvik, Elin Grundberg, Bing Ge, Bram van der Eerden, Jeroen van de Peppel, Matthew A. Hibbs, Cheryl L. Ackert-Bicknell, Kwangbom Choi, Daniel L. Koller, Michael J. Econs, Frances M. K. Williams, Tatiana Foroud, M. Carola Zillikens, Claes Ohlsson, Albert Hofman, André G. Uitterlinden, George Davey Smith, Vincent W. V. Jaddoe, Jonathan H. Tobias, Fernando Rivadeneira, David M. Evans

(TBLH-BMD) = total-body less head BMD, (LL-BMD) = lower limb BMD, (UL-BMD) = upper limb BMD, (SK-BMD) = skull BMD, (GENE) = closest gene, (POS) = position in the genome based on hg18, (EAF) = effect allele frequency, (β) = estimates of effect size expressed as adjusted SD per copy of the effect allele (EA), (SE) = standard error of β, (P) = pvalue, (I²) = Cochran's Q statistic evaluating heterogeneity, (P_HET) = evidence of heterogeneity and

*Sample sizes used for SK-BMD genome-wide meta-analysis.

**Please note that PTHLH is also located at the 12p11.22 locus containing KLHDC5, RSPO3 is also located at the 6q.22.32 locus containing CENPW, FAM3C and CPED1 are also located at the 7q.31.31 locus containing WNT16, TNFRSF11B is also located at the 8q.24.12 locus containing COLEC10, LGR4 is also located at the 11p14.1 locus containing LIN7C and LRP5 is also located at the 11q13.2 locus containing PPP6R3.