Time-courses of the BBB permeability to valproic acid, nicotine and inulin in the neonatal and adult rats (in vivo) and the neonatal and adult BBB models (in vitro).

The time-courses of the brain/perfusate ratios of valproic acid, nicotine and inulin in the neonatal (2 weeks, filled circles) and adult (8 weeks, open circles) rats (in vivo) (left panels in A, B and C, respectively). The time-courses of the transferred volume of valproic acid, nicotine and inulin in the neonatal (2 weeks, filled circles) and adult (8 weeks, open circles) BBB models (in vitro) (right panels in A, B and C, respectively). Data are means ± SEM (n = 3−6 (in vivo) and n = 4−12 from 2–3 separate experiments (in vitro)).