Time-courses of the BBB permeability to valproic acid, nicotine and inulin in the neonatal and adult rats (<i>in vivo</i>) and the neonatal and adult BBB models (<i>in vitro</i>).

<p>The time-courses of the brain/perfusate ratios of valproic acid, nicotine and inulin in the neonatal (2 weeks, filled circles) and adult (8 weeks, open circles) rats (<i>in vivo</i>) (left panels in A, B and C, respectively). The time-courses of the transferred volume of valproic acid, nicotine and inulin in the neonatal (2 weeks, filled circles) and adult (8 weeks, open circles) BBB models (<i>in vitro</i>) (right panels in A, B and C, respectively). Data are means ± SEM (n = 3−6 (<i>in vivo</i>) and n = 4−12 from 2–3 separate experiments (<i>in vitro</i>)).</p>