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The two most significant SNP-gene pairs identified using the Likelihood Ratio Test.

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posted on 2012-08-17, 02:46 authored by Paras Garg, Christelle Borel, Andrew J. Sharp

Results for (A) PSCD4 and (B) TBC1D7. In each plot the three panels show variation of gene expression with respect to maternally inherited SNPs, paternally inherited SNPs and two classes of heterozygotes, respectively. Box plots show the distributions of gene expression for CEU (circles) and YRI offspring (crosses) with respect to maternally (MAT) and paternally (PAT) inherited SNPs. Note that unlike loci identified using separate association with maternal and paternal alleles where a difference in gene expression level is seen for only one of the two parental alleles, for both genes the A and C alleles have opposite effects on gene expression when inherited maternally versus paternally.

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