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The effects of LPS on DNMT gene expression.
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posted on 2015-03-20, 04:04 authored by Xueqi Qu, Maren Pröll, Christiane Neuhoff, Rui Zhang, Mehmet Ulas Cinar, Md. Munir Hossain, Dawit Tesfaye, Christine Große-Brinkhaus, Dessie Salilew-Wondim, Ernst Tholen, Christian Looft, Michael Hölker, Karl Schellander, Muhammad Jasim UddinExpression of genes that encode the enzymes responsible for methylating CpG sites of DNA were quantified by qRT-PCR including the maintenance methyltransferase DNMT1 and the de novo methyltransferase DNMT3a in moDCs in response to LPS exposure (24 h) compared with control. The results were combined from three independent experiments and each experiment was performed in triplicate. The data were represented as the mean ± standard deviations (SD) (* P < 0.05; ** P < 0.01).
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HDAC activityHDAC inhibitorLipopolysaccharide Histone acetylationlipopolysaccharide LPSSulforaphane Epigenetically Regulates Innate Immune ResponsesIRF 6gene expressionsDNMT 3a gene expressionLPS stimulationDNMT 1 genetbpilporcine moDCsHDAC inhibitor SFNnfCD 86 expressiontlrmoDCs differentiationtgfcell culture supernatantscell apoptosishistone deacetylasesDNA methyltransferasetnfMD 2 gene expressionresponseHDAC family gene expressionsDendritic cells
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