The effect of leptin administration on motor function recovery in the open-field test.

(A) Recovery of motor functioning was determined using the Basso-Beattie-Bresnahan (BBB) locomotor scale. Leptin administration enhanced the recovery of motor functions at 1, 3, 7 and 28 d after SCI when compared with vehicle-treated controls. (B) The BBB sub-scores (7–28 d post-SCI) were significantly higher following leptin administration. In all cases, the values represent the mean ± SEM; *p<0.05 versus the vehicle control group.