The effect of HIV related proteins on hippocampal inflammation was measured in adolescent WT and HIV-1 tg rats.

<p><i>A</i>) Analysis of hippocampal gene expression of inflammatory markers showed increased expression of the potent chemokine, <i>Mcp-1</i>, in non-drug treated HIV-1 tg rats compared to WT controls (*<i>p</i><0.05). <i>B</i>) In contrast, once daily meloxicam administration attenuated <i>Mcp-1</i> expression in HIV-1 tg rats, normalizing inflammatory gene expression to WT levels (<i>p</i>>0.05). Data are presented as mean ± SEM.</p>