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T-maze spontaneous alternation of the offspring.

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posted on 2015-07-28, 03:15 authored by Thiago Berti Kirsten, Gabriela P. Chaves-Kirsten, Suene Bernardes, Cristoforo Scavone, Jorge E. Sarkis, Maria Martha Bernardi, Luciano F. Felicio

The effects of prenatal LPS (100 μg/kg) and zinc (ZnSO4; 2 mg/kg) exposure at gestational day 9.5 on T-maze spontaneous alternation in young male rat offspring (PND 29). Five-session scores: 0, no alternations; 1, one alternation; 2, two alternations; 3, three alternations; and 4, four alternations. SAL+SAL, prenatal saline injection and another saline injection 1 h later; LPS+SAL, prenatal LPS injection and a saline injection 1 h later; LPS+Zn, prenatal LPS injection and a zinc injection 1 h later (n = 10 rats/group). **p < 0.01 compared with the SAL+SAL group; #p < 0.05 compared with the LPS+Zn group (Kruskal-Wallis test followed by Dunn’s test). The data are expressed as the median (minimum and maximum).

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