TLR7 and TLR9 blockade does not impact virus load or pDC kinetics.

<p>(A) SIV RNA copies/ml of plasma for untreated (n = 5) and DV056-treated (n = 4) macaques over time as determined by quantitative RT-PCR. Shown are virus loads for each animal in untreated and DV056-treated groups as well as geometric means for each group. (B) Absolute counts of pDC in blood for untreated and DV056-treated macaques over time. Shown is the percent change in cell counts relative to preinfection levels for each animal in untreated and DV056-treated groups as well as means for each group. (C) Percent of CCR7+ pDC in blood over time. Shown is the percent pDC expressing CCR7 before and after SIV infection for each animal in untreated and DV056-treated groups as well as the means for each group.</p>