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TLR4 deficiency suppressed inflammatory and fibrotic responses in diabetic kidney.

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posted on 2014-05-19, 03:23 authored by Jin Ma, Steven J. Chadban, Cathy Y. Zhao, Xiaochen Chen, Tony Kwan, Usha Panchapakesan, Carol A. Pollock, Huiling Wu

The expression of endogenous TLR ligands was upregulated in WT-DN kidneys and TLR4−/−diabetic kidneys at week 6 compared with WT non-diabetic controls. (A). Gene expression of IL-6 (A), TNF-α (B), CCL2 (C), CXCL10 (D), TGF-β (E) and fibronectin (F) were upregulated in WT mice with diabetes, but suppressed in TLR4−/− mice with diabetes, as measured by RT-PCR. Data are presented as means ± SD; ** p<0.01; *** p<0.001. The number of animals per group was described in Figure 1.

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