Suppression of viral replication in cells in the peripheral blood.

Mice receiving the HIV Gag SL-9 specific TCR (left and right panels) or the non-specific control TCR (middle panels) were either left uninfected (left panels) or were infected with HIV-1NL-HSA-HA (right and middle panels) and assessed for HIV (HSA-HA) expressing, human CD45+ cells (top panels) and CD4 and CD8 expression by gated CD3+ T cells (bottom panels). Mice were assessed by flow cytometry for these cell surface markers A. 2 weeks, and B. 6 weeks post infection. The numbers indicate the percentages of cells that exist with each of the respective quadrants. The data are representative of the phenotypic profile of 1 mouse of 6 mice receiving the SL-9 specific TCR, and 1 mouse of 6 receiving the control TCR and are representative of 3 separate experiments with a minimum of 3 mice in each experimental group.