Structure comparisons of closed aquaporins from <i>P. pastoris</i> and spinach.

<p>(A) Comparison of the Aqy1 from <i>P. pastoris</i> (left panel) with the spinach aquaporin SoPIP2;1 (right panel) shown as HOLE representation. The pore is occluded by the N terminus in Aqy1, and by loop D in SoPIP2;1. (B) The pore diameter of closed Aqy1 (yellow), closed SoPIP2;1 (green), and constitutively open bAQP1 (black) structures calculated with program HOLE. (C) Stereo-view of the superposition of SoPIP2;1 (green) onto Aqy1 (yellow). Residues identified in the narrowest parts of the pores of the respective aquaporin are shown in stick representation.</p>