Structure comparison of c-Src and JAK1 structures.

(A) c-Src kinase domain (this work) is superimposed with JAK1 kinase domain (pdb: 3EYG) using the Ca atoms of kinase domain as the reference. c-Src is shown yellow, while JAK1 is shown in magenta. (B) Predicted c-Src ligand-binding pocket is shown in grey dots. (C) Predicted JAK1 ligand-binding pocket is shown in grey dots. Ligand-binding pocket is predicted using POCASA[30].