Structural model Plasmodium falciparum lactate dehydrogenase (pfLDH) (PDB: 1CEQ) with NADH binding site (yellow color)

(A). Superimposition of the best conformation of GA (in purple), CQ (in yellow) and NADH (in orange) in the active site pocket of P. falciparum enzyme lactate dehydrogenase pfLDH) (B). 2-D diagrams illustrating protein-ligand interactions: (C) Compound CQ; (D) Compound GA.