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Statin treatment and P. aeruginosa infection modulate the host immune response.
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posted on 2014-07-10, 02:59 authored by Emma Hennessy, Julie O'Callaghan, Marlies J. Mooij, Claire Legendre, Olga Camacho-Vanegas, Sandra C. Camacho, Claire Adams, John A. Martignetti, Fergal O'GaraA549 cells were treated with 10 µM simvastatin or an equivalent amount of DMSO (VEHICLE) for 24 hours. Untreated and statin-treated cells were subsequently infected with P. aeruginosa PAO1 for 3 hours at MOI 50∶1. The expression of (A) KLF2 (B) KLF6 (C) IL-8 (D) CCL20 and (E) TLR5 was analysed in uninfected cells, and in the presence of vehicle, simvastatin (SIM), P. aeruginosa (PAO1) and simvastatin and PAO1 combined (SIM+PAO1). *P, ≤0.05, **P, ≤0.01, ***P, ≤0.001.
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cell biologyMolecular cell biologygeneticsgene expressionimmunologyImmune responseinflammationImmune systemInnate immune systemimmunityImmune activationmicrobiologybacteriologyGram negative bacteriaMedical microbiologyMicrobial pathogensBacterial pathogensInfectious diseasesBacterial diseasesPseudomonas infectionsPathology and laboratory medicinepathogenesisHost-pathogen interactionsmodulate
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