Spatial pattern of deafferentation affects post-traumatic reorganization of activity.

A Burst rate vs the trauma volume, for focal (A1) and diffuse (A2) trauma scenarios and different schemes of HSP: local HSP (open red circles and open black squares); “global HSP” (closed red circles and closed black squares). B Network-averaged firing rate of PY model neurons vs the time since deafferentation, for focal (B1) and diffuse (B2) trauma pattern scenarios. Red: small trauma volume (). Black: larger trauma volume (). Solid lines: Local HSP scheme. Dashed lines: Global HSP scheme. C1: Burst rate vs trauma volume for baseline model (squares) and the model in which the upregulating component of HSP averaged over global network activity (triangles). C2: Burst rate vs trauma volume for baseline model (squares) and the model in which downregulating component of HSP was omitted and upregulating component of HSP averaged over global network activity (open diamonds). All scenarios considered are for focal trauma. D1: Averaged PY firing rate vs neuronal location in the network (left plot), and network averaged PY firing rate vs trauma volume (right plot). Keys are the same as in C1. D2: Averaged PY firing rate vs neuronal location in the network (left plot), and network averaged PY firing rate vs trauma volume (right plot). Keys are the same as in C2. Boundaries between traumatized and intact regions are demarcated with dashed lines. E1 Averaged firing rate of intact PY neurons at the boundary between deafferented and intact regions, vs the trauma volume, for scenarios shown in C1. Keys are the same as in C1. E2: Averaged firing rate of intact PY neurons at the boundary between deafferented and intact regions, vs the trauma volume, for scenarios shown in C2. Keys are the same as in C2. In D–E, trauma volume parameter was .