Figure_5.tif (2.62 MB)
Some TICs are more resistant to anti-tumor drugs than gastric tumor cell lines and other TICs.
figure
posted on 2013-08-28, 01:32 authored by Hiroshi Fukamachi, Hyang Sook Seol, Shu Shimada, Chikako Funasaka, Kanako Baba, Ji Hun Kim, Young Soo Park, Mi Jeung Kim, Keiji Kato, Mikito Inokuchi, Hiroshi Kawachi, Jeong Hwan Yook, Yoshinobu Eishi, Kazuyuki Kojima, Woo Ho Kim, Se Jin Jang, Yasuhito YuasaHGC-1, HGC-2 and HGC-4 tumor cells, and MKN45 and MKN74 tumor cell lines are seeded on day 0, treated with various concentrations of (A) doxorubicin, (B) 5-fluorouracil, and (C) doxifluridine from days 1 to 14, and cell numbers on day 14 are determined by MTT assay. Black and blue asterisks show that HGC-1 and/or HGC-4 cells are significantly (**, P<0.01; *, P<0.05 by Student’s t-test) more resistant to the drugs than MKN45 and MKN74 cell lines, respectively, while pink and brown asterisks indicate that HGC-4 cells are significantly (**, P<0.01; *, P<0.05 by Student’s t-test) more resistant to the drugs than HGC-1 and HGC-2 cells, respectively.
