Silencing of CHOP by siRNA inhibited induction of DR5 upregulation by casticin and apoptosis by co-treatment with casticin and TRAIL in BGC-823 cells.

<p>Effects of siRNA for CHOP on the action of casticin-induced DR5 and CHOP expression (A and B) using western blot analysis and TRAIL-mediated apoptosis (C) in BGC-823 cells (mean±SD, <i>n</i> = 3). <sup>*</sup><i>P<0.05</i> vs. treatment with DMSO; <sup>#</sup><i>P<0.05</i> vs. treatment with 1 µmol/l casticin plus 50 ng/ml TRAIL in control and scRNA transfected cells.</p>