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Serum HBV DNA titer, HBeAg level, and genotype are associated with cccDNA CpG island II methylation.

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posted on 2014-10-22, 03:06 authored by Yongmei Zhang, Richeng Mao, Ran Yan, Dawei Cai, Yijun Zhang, Haoxiang Zhu, Yaoyue Kang, Hongyan Liu, Jinyu Wang, Yanli Qin, Yuxian Huang, Haitao Guo, Jiming Zhang

(A) Correlation between serum HBV DNA levels and cccDNA CpG island II methylation in patients with chronic HBV infection (r2 = 0.18, P<0.05). (B) The density of CpG island II methylation was significantly higher in patients with low serum HBV DNA level (Log10HBV DNA<5) compared to those with high serum HBV DNA level (Log10HBV DNA≥5). (C) HBeAg-negative patients had higher rate of cccDNA CpG II methylation than HBeAg-positive patients. (D) Genotype C HBV patients had higher rate of CpG II methylation than patients with genotype B HBV infection.

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