Sequence divergence and prediction of B-cell linear epitopes and intrinsically unstructured/disordered regions in <i>L. braziliensis</i> Cathepsin L-like and its orthologs.

<p>Alignment of <i>L. braziliensis</i> Cathepsin L-like (TritrypDB ID: LbrM.08.0830) and orthologous proteins in <i>L. infantum</i> (TritrypDB ID: LinJ.08.0960), <i>T. cruzi</i> (TritrypDB ID: TcCLB.509429.320), <i>H. sapiens</i> (RefSeq ID: NP_003784.2) and <i>C. familiaris</i> (RefSeq ID: XP_005631485.1). The yellow boxes mark predicted B-cell epitopes, and the gray boxes mark predicted disordered regions. The continuous black underlined amino acid sequences in the LbrM.08.0830 protein represent one potential B-cell epitopes predicted by Bepipred, and the colors highlight amino acids conserved between the <i>T. cruzi</i>, <i>C. familiaris</i> and <i>H. sapiens</i> sequences and <i>L. braziliensis</i>.</p>