Schematics of breeding tubercle organization and regulation.

<p>(A) Schematic of cellular composition of breeding tubercles and regular epidermis. The different layers and cell types are colour-coded. On the right side, the sites of cellular structures and junctions shown in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004048#pgen-1004048-g003" target="_blank">Figure 3</a> (TEM) are indicated. (B) Model for the dual role of TAp63/p53 on keratinocyte proliferation and differentiation, and its connection to ΔNp63. For details, see text.</p>