Schematic showing domain organization of TPO, as determined from sequence analysis.

<p>The protein sequence is coding an N-terminal propeptide domain (yellow), a MPO-like domain (green) with a catalytic heme (red) that is connected to a CCP-like (Shamrock green), and an EGF-like (cyan-blue) domains, an anchoring trans-membrane domain (dark-blue) and an intracellular domain (dark-magenta).</p>