Fig_1.tif (876.54 kB)
Schematic showing domain organization of TPO, as determined from sequence analysis.
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posted on 2015-12-01, 16:01 authored by Sarah N. Le, Benjamin T. Porebski, Julia McCoey, James Fodor, Blake Riley, Marlena Godlewska, Monika Góra, Barbara Czarnocka, J Paul Banga, David E. Hoke, Itamar Kass, Ashley M. BuckleThe protein sequence is coding an N-terminal propeptide domain (yellow), a MPO-like domain (green) with a catalytic heme (red) that is connected to a CCP-like (Shamrock green), and an EGF-like (cyan-blue) domains, an anchoring trans-membrane domain (dark-blue) and an intracellular domain (dark-magenta).
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Autoantigenicity Thyroid peroxidaseTPO structureThyroid hormonesapical membraneTPO dimerdimer organisationimmunodominant regionssequence features20 yearssurface regionsdimer interfacedomain rearrangementsOligomeric Statempoenzyme functionEpitope mapping studiesepitope fragmentationmodelling approachsteric hindranceThyroid Peroxidase
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