Fig_4.tif (465.88 kB)
Schematic representation of the mnemonic model for the mammalian glucokinase.
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posted on 2015-04-14, 02:49 authored by Pedro Saa, Lars K. NielsenThis model proposes a slow conformational transition from a low-affinity state (E*) to a high-affinity state (E) that can be enhanced with increasing glucose concentration yielding the observed cooperative behaviour.
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parameterizationreaction elasticity regionsphosphoenolpyruvate carboxylaseReaction kineticsframeworkreaction formalismgrparameter setsoligomeric enzyme kineticskinetics spacereference statebehaviourfeatures underpinningultrasensitive responsereference dataMWC modelgraspEscherichia coliGeneral Reaction Assemblyuniform samplingenzyme catalysisEnzymatic Reactions Kinetic modelssampling strategieskjSampling Platformmonomeric cooperativityEfficient SamplingGeneral Framework
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