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Schematic representation of the contribution of SslE to E.coli pathogenesis.

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posted on 2015-03-19, 04:44 authored by Maria Valeri, Silvia Rossi Paccani, Magdalena Kasendra, Barbara Nesta, Laura Serino, Mariagrazia Pizza, Marco Soriani

Gut mucus forms two layers, an inner firm mucus layer devoid of bacteria, and an outer layer that is not sterile and is a major habitat for commensal bacteria. E. coli can penetrate this barrier through the SslE-mediated enzymatic degradation of the mucus, targeting epithelial cells. This interaction will eventually lead to IL-8 release and neutrophils recruitment.

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