Figure_1.tif (1.08 MB)
Schematic of the translation initiation signaling network.
figure
posted on 2011-11-10, 01:14 authored by Joshua Lequieu, Anirikh Chakrabarti, Satyaprakash Nayak, Jeffrey D. VarnerGrowth factors trigger receptor dimerization and the formation of adaptor complexes which activate PI3K. PI3K then signals through PIP2/3 to activate Akt. Activated Akt can then activate mTORC1 either directly or by phosphorylating TSC1/2, an inhibitor of Rheb. Activated mTORC1 can phosphorylate 4EBP1 and activate S6K1, two necessary checkpoints for translation initiation. mTORC1 can also phosphorylate IRS-1, a negative feedback which inhibits formation of the adaptor complex and attenuates insulin signaling.