Fig_9.tif (964.86 kB)
Schematic of proposed mechanism of IFNγ-induced suppression of AQP-1.
figure
posted on 2015-03-20, 05:00 authored by Michael S. Dicay, Christina L. Hirota, Natalie J. Ronaghan, Michael A. Peplowski, Raza S. Zaheer, Colin A. Carati, Wallace K. MacNaughtonWhile IFNγ activates both STAT1 and STAT3 in a JAK-dependent manner, only activation of STAT3 plays a role in the reduced expression of AQP1. IRF2 may play a role in the constitutive expression of AQP1. IFNγ suppresses IRF2, but this does not appear to play a role in reduced AQP1 expression.
