Figure_5.tif (2.27 MB)
Schematic diagram of Aβ dimers with and without copper.
figure
posted on 2013-03-12, 09:00 authored by Francis Hane, Gary Tran, Simon J. Attwood, Zoya LeonenkoWithout copper, the most favorable conformation of the Aβ dimer involves an anti-parallel conformation (A). With the addition of copper, Aβ adopts a parallel dimer conformation (B) stabilized by the occupied copper binding sites (C).