SR-uPA<sup>+/0</sup> macrophages adopt full M2 phenotype in the heart.
2013-03-12T09:03:09Z (GMT) by
<p>Picrosirius red stain for collagen in hearts from <b>A.</b> 5 weeks old, <b>B.</b> 7 weeks old, and <b>C.</b> 11 weeks old SR-uPA<sup>+/0</sup> mice. Bars represent 100 µm. <b>D.</b> Fold increase in expression of <i>Arg1</i>, <i>Ym1</i> and <i>Fizz1</i> mRNA in CD-45+ cell fractions from hearts of SR-uPA<sup>+/0</sup> mice at time-points of increasing fibrosis. Star (*) indicates significant <i>P</i> values versus 4–5 week time-point. N = 4–7 mice per time-point. <b>E.</b> Comparison of <i>Arg1</i> expression from bone marrow macrophages, cardiac macrophages (CD45+) and cardiac CD45 negative fraction (CD45–). Pound (#) indicates significant <i>P</i> values versus other cell types, n = 6–7 mice per condition. <b>F.</b> Arginase activity in cardiac explant conditioned media from SR-uPA<sup>+/0</sup> and NTG hearts, n = 7–8 mice per genotype.</p>