SPM results for the voxel-wise correlation between changes in metabolism and changes in self-reports of cocaine craving (Neutral - Cocaine-cues) for the Placebo and the Methylphenidate conditions (p<0.005 uncorrected, cluster size >200 voxels).

<p>For Placebo the correlations were negative (decreases in metabolism associated with increases in craving) whereas with Methylphenidate these were positive (increases in metabolism associated with increases in craving).</p>