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SOX-17 over-expression or BMP2-supplementation is sufficient to to resyore calcium transients and synchrony in HDAC1-KD ES cells.

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posted on 2012-09-12, 02:41 authored by Eneda Hoxha, Erin Lambers, John A. Wasserstrom, Alexander Mackie, Veronica Ramirez, Tatiana Abramova, Suresh K. Verma, Prasanna Krishnamurthy, Raj Kishore

A. Calcium uptake and release experiments indicating synchrony and response to stimuli of beating EBs in mES, mES-HDAC1-KD, mES-HDAC1-KD embryoid bodies treated with BMP2 for the first two days of differentiation. B. Percentage of EBs that respond to external stimuli and are synchronized (example shown in A). C. RT-PCR showing mRNA expression levels of Connexin-43 and D. organization of Connexin 43, in mES, mES-HDAC1-KD derived embryoid bodies and mES-HDAC1-KD embryoid bodies treated with BMP2 for the first two days of differentiation. Data in all panels are represented as mean +/− SD and n = 3.

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