Representation of pocket and ligand properties for 9 pocket-ligand pairs seen in 3 different clusters.

<p>(A) Average pocket and ligand profiles of cluster a are represented on star plot. Dashed lines represent pocket and ligand properties of complexes beta-glucosidase bound to IMH ligand (pdb code 1B8O, magenta dashed line) and purine nucleoside phosphorylase bound to GI1 ligand (pdb code 2J7D, blue dashed line). (B) Average pocket and ligand profiles of cluster c are represented on star plot. Dashed lines represent the pocket and ligand properties of 4 cAMP-dependent protein kinases bound to M77 ligand (pdb code 1Q8W, blue dashed line), to 1QP ligand (pdb code 1YDR, dark green dashed line), to 1QS ligand (pdb code 1YDS, green dashed line) and to HFS ligand (pdb code 2ERZ, orange dashed line). (C) Average pocket and ligand profiles of cluster e are represented on star plot. Dashed lines represent the pocket and ligand properties of 3 cAMP-dependent protein kinases bound to BD2 ligand (pdb code 1RE8, magenta dashed line), to B1L ligand (pdb code 1REJ, orange dashed line) and to R69 ligand (pdb code 1XH9, blue dashed line).</p>