Relationship between post-treatment WFA<sup>+</sup>-M2BP values and HCC development.

<p>The distribution of WFA<sup>+</sup>-M2BP values was plotted. The dashed line indicates the 2.0 COI for WFA<sup>+</sup>-M2BP. The 16 patients who developed HCC were stratified according to the duration from SVR to HCC development in 5-year increments. Each time point is designated by a distinct symbol as indicated. 222 patients did not develop HCC, and 209 of these 222 patients (94.1%) were in the post-treatment WFA<sup>+</sup>-M2BP ≤ 2.0 COI group (white circles). During the follow-up period, 5 of 18 patients (27.8%) developed HCC in the post-treatment WFA<sup>+</sup>-M2BP > 2.0 COI group, which was significantly higher than the rate in the post-treatment WFA<sup>+</sup>-M2BP ≤ 2.0 COI group (5.0%, <i>P</i> < 0.001). In the post-treatment WFA<sup>+</sup>-M2BP > 2.0 COI group, 4 of 5 cases developed HCC within 5 years after IFN treatment (black circles).</p>