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Regulation of matrix metalloproteinases and its inhibitors in the aorta of AngII-infused rats: Restoration by statins.

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posted on 2013-02-20, 22:06 authored by Raúl Rodrigues Díez, Raquel Rodrigues-Díez, Carolina Lavoz, Sandra Rayego-Mateos, Esther Civantos, Juan Rodríguez-Vita, Sergio Mezzano, Alberto Ortiz, Jesús Egido, Marta Ruiz-Ortega

A. Gene expression of MMP-9 and TIMP-1 was evaluated by real time PCR and data are expressed as mean±SEM of 10 animals per group, *p<0.05 vs control; # p<0.05 vs AngII. B. Evaluation of matrix balance by the ratio MMP-9 vs TIMP-1. Values higher or lower than 1 reflect degradation or accumulation, respectively, of matrix proteins.

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