Rapamycin (RAP) improves survival in a mouse model of polyposis.

Kaplan-Meier survival curves where TAM administration was used to induce Apc mutation-dependent colon polyposis in CDX2P-CreER^T2 Apc^fl/fl mice and then mouse cohorts were treated with vehicle (dotted) or RAP (solid) and monitored for survival. Log-rank test comparing the groups treated with RAP or vehicle revealed a significant difference in survival (p = 0.03, N = 6 mice per group).