Radial Arm Water Maze.

A) Scopolamine-treated mice (SCP) made more errors at learning (trials 1–4) and remembering (trial 5) the hidden platform location than control mice (Ctrl) did (n = 9-10/group). B) Long-term (24 h) memory of mice was evaluated by averaging the entries into the previous target arm during the first trial of days 2–12. SCP mice entered into the last target arm significantly less than control mice. C) 129S6/Tg2576 mice made significantly more errors during the learning phase (trials 1–4) of the radial arm water maze test compared to WT control mice. D) The number of entries into the last target arm were not different between 129S6/Tg2576 mice and WT control mice (n = 19-20/group). Data are mean ± SEM; 6A and 6C: *p < 0.05; **p < 0.01; ***p < 0.001 (repeated measures ANOVA); 6B and 6D: ***p < 0.001 (repeated measures ANOVA was used for Fig 6A and 6C; Student’s t-test was used to calculated p values for Fig 6B and 6D).