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RMSF of the A-loop region and IC₅₀ values of imatinib for the studied tyrosine kinases and the designed triple mutants of Src.

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posted on 2015-11-25, 03:24 authored by Silvia Lovera, Maria Morando, Encarna Pucheta-Martinez, Jorge L. Martinez-Torrecuadrada, Giorgio Saladino, Francesco L. Gervasio

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binding kinetics mutation imatinib resistance Kinase Conformational Dynamics T 315I gatekeeper Drug Resistance cancer patients tyrosine kinases ABL kinase domain dynamics simulations Myeloid leukemia microcalorimetry experiments DFG motif energy calculations binding mechanism energy landscape

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RMSF of the A-loop region and IC50 values of imatinib for the studied tyrosine kinases and the designed triple mutants of Src.

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RMSF of the A-loop region and IC₅₀ values of imatinib for the studied tyrosine kinases and the designed triple mutants of Src.